Research Keywords 【 display / non-display

  • bioactive lipids, metabolome analysis, soft-ionization mass spectrometry, allergy and inflammation, essential fatty acids, Lipid Metabolome, Lipid Metabolism, Lipid Nutrition, Lipid Biochemistry

Research Pursuits 【 display / non-display

  • We have investigated cellular functions of lipid molecules using the techniques in biochemistry, molecular cell biology and mass spectrometry. Original research themes rather than fashionable topics are conducted in our laboratory. Our main research interests are as follows. 1) Metabolism and functions of bioactive lipids: Biological activities including of an inhibitory activity toward cancer cell invasion and neurotrophic effects on cultured embryonic hippocampal neurons by cyclic phosphatidic acid (cPA) and lysophosphatidic acid (LPA) have been studied as well as their metabolism. 2) Lipid metabolome analysis based on mass spectrometry. Investigations of phospholipid and steroid molecules using soft-ionization mass spectrometry are performed. 3) Lipid mediators involved in cellular stress responses. We demonstrated the rapid induction of sterylglucoside(CG)by heat shock in human cultured fibroblasts to suggest that CG may act as a lipid mediator in an early stage of the stress signal transduction system. 4) Biological activities of omega-3 fatty acids. I have reviewed the recent research papers concerned with omega-3 fatty acids to return the results of research to society at large from the lipid nutritional point of view.

Educational Pursuits 【 display / non-display

  • I deliver lectures about biochemistry to undergraduate students and supervise their graduation thesis. I also supervise a dissertation for master- and doctor-course students by co-investigating new research projects of lipid biochemistry. My educational goal is to produce excellent human resources with remarkable problem-solving abilities and fundamental knowledge. Knowledge is not enough, we must apply. Willing is not enough, we must do. With this point in mind I make much account of teaching how to get knowledge, and how to apply it. I regard individual initiative as important. I want them to know new-found excitement during studying in the undergraduate classes or graduate course. Higher education of good quality should be built on highly advanced research. Therefore, I attempt to develop original research by investigating new research project of my research field, lipid biochemistry. I also promote and implement joint research with collaborators outside the University. This collaboration contributes substantially to our educational activities.

Academic 【 display / non-display

  • The University of Tokyo, University, 1978/03, Graduated, JAPAN

  • The University of Tokyo, Graduate School(Master's Course), 1981/03, Completed, JAPAN

  • The University of Tokyo, Graduate School(Doctor's Course), 1984/03, Completed, JAPAN

Campus Career 【 display / non-display

  • Graduate School of Humanities and Sciences, Research Organization, the Core Section The Natural/Applied Sciences Division, Professor

  • Faculty of Core Research Natural Science Division, Professor

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Life Sciences, Professor

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Life Sciences, Professor

  • Graduate School of Humanities and Sciences, Education Organization, Master's Program Life Sciences, Professor

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Research Field 【 display / non-display

 

Books 【 display / non-display

  • やさしい「細胞の科学」

    オーム社1999.03, 室伏きみ子、小林哲幸 共著, Textbook

  • バイオサイエンス事典

    II.生体物質と代謝, 朝倉書店, 2002.01, 小林哲幸ほか, 太田次郎編, Dictionary, 34-60

  • ライフサイエンス入門

    脳の働きと脂質;食環境の大切さ, オーム社, 2002.04, 小林哲幸, 室伏きみ子編, Book, 35-47

  • スタンダード栄養・食物シリーズ3「人体の構造と機能」II.生化学

    第8章 脂質と生体膜, 東京化学同人, 2003.05, 小林哲幸, 近藤和雄ほか編, Textbook, 67-82

  • 健康・栄養科学シリーズ「人体の構造と機能及び疾病の成り立ち」総論

    第3章 糖質と脂質の化学 B.脂質の化学 , 南江堂, 2005.02, 小林哲幸, 香川靖雄ほか編, Textbook, 97-103

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Papers 【 display / non-display

  • A Critical Review of the Consensus Statement from the European Atherosclerosis Society Consensus Panel 2017

    Pharmacology, vol.101(3-4)(p.184 - 218), 2018.01, Harumi Okuyama, Tomohito Hamazaki, Rokuro Hama, Yoichi Ogushi, Tetsuyuki Kobayashi, Naoki Ohara, Hajime Uchino., Survey, Research paper (scientific journal), Coauthor

  • A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C.

    FASEB J, vol.31(4)(p.1301 - 1322), 2017.04, Makino, A., Abe, M., Ishitsuka, R., Murate, M., Kishimoto, T., Sakai, S., Hullin-Matsuda, F., Shimada, Y., Inaba, T., Miyatake, H., Tanaka, H., Kurahashi, A., Pack, C.G., Kasai, R.S., Kubo, S., Schieber, N.L., Dohmae, N., Tochio, N., Hagiwara, K., Sasaki, Y., Aida, Y., Fujimori, F., Kigawa, T., Nishibori, K., Parton, R.G., Kusumi, A., Sako, Y., Anderluh, G., Yamashita, M., Kobayashi, T., Greimel, P., Kobayashi, T., Original, Research paper (scientific journal), Coauthor

  • Group X Secreted Phospholipase A2 Releases omega-3 Polyunsaturated Fatty Acids, Suppresses Colitis and Promotes Sperm Fertility

    J. Biol. Chem., vol.291(13)(p.6895 - 6911), 2016.01, Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M., Original, Research paper (scientific journal), Coauthor

  • Medicines and Vegetable Oils as Hidden Causative of Cardiovascular Disease and Diabetes

    Pharmacology, vol.98(98)(p.134 - 170), 2016, Harumi Okuyama, Peter H Langsjoen, Naoki Ohara, Yoko Hashimoto, Tomohito Hamazaki, Satoshi Yoshida, Tetsuyuki Kobayashi, Alena M. Langsjoen., Survey, Research paper (scientific journal), Coauthor

  • Novel role of group VIB Ca2+-dependent phospholipase A2γ in leukocyte-endotherial cell interaction in acute inflammation: an intravital microscopic study in rat mesentery.

    J. Trauma and Acute Care Surgery, vol.79(5)(p.782 - 789), 2015, Mitsuaki Kojima, Junichi Aiboshi, Masahiro Shibata, Tetsuyuki Kobayashi, and Yasuhiro Otomo, Original, Research paper (scientific journal), Coauthor

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Published Article 【 display / non-display

  • 古くて新しい作物、荏胡麻から見た脂質栄養学

    学士会会報, 2005, 小林哲幸, Other article

  • リゾリン脂質メディエーターとしてのリゾホスファチジン酸と環状ホスファチジン酸の存在、代謝および生理機能

    蛋白質核酸酵素, 1999, 小林哲幸、室伏きみ子, Coauthor, Introduction and explanation (scientific journal)

  • 細胞分化・ストレス応答とステリルグルコシド

    蛋白質核酸酵素, 1999, 室伏きみ子、小林哲幸, Coauthor, Introduction and explanation (scientific journal)

  • 脂質の代謝と生体内での役割

    Surgery Frontier, 2011, Tetsuyuki Kobayashi, Single Author, Introduction and explanation (scientific journal)

  • 求められる、油脂製品の安全性とリスク評価

    ファルマシア, 2011, Tetsuyuki Kobayashi, Single Author, Introduction and explanation (scientific journal)

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Review Papers 【 display / non-display

  • 数種の食用油に含まれる微量有害因子に関する研究 厚生労働科学研究費補助金 食品の安全性高度化推進研究事業 平成16年度研究報告書

    Ⅱ-7.大豆レシチン画分中の微量成分と培養細胞を用いた生理活性評価, 2005.03, 小林哲幸, 奥山治美, Private Grants-in-Aid for Scientific Research Report

  • ステリルグルコシドを介した細胞のストレス初期応答機構の解析

    2005.03, 小林 哲幸, Public Grants-in-Aid for Scientific Research Report

  • 数種の食用油に含まれる微量有害因子に関する研究 厚生労働科学研究費補助金 食品安全確保研究機構 平成15年度研究報告書

    Ⅱ-8.ステリルグルコシドの生理活性に関する研究, 2004.04, 小林哲幸, 奥山治美, Private Grants-in-Aid for Scientific Research Report

  • 細胞のストレス防御応答に関与するステリルグルコシドの合成誘導と機能の解析

    2002.03, 小林 哲幸, Public Grants-in-Aid for Scientific Research Report

  • DHAの生理機能と必要量 「生体中の分布、存在状態、代謝および生理作用」(財)日本水産油脂協会

    2002, 小林哲幸ほか, Investigative Report(Field Research etc.), Joint Work

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Presentations 【 display / non-display

  • Lipid analysis of brain tissues in a mouse model for cellular inositol depletion

    Chinatsu Tabata, Tetsuo Ohnishi, Chie Shimamoto, Takeo Yoshikawa, Tetsuyuki Kobayashi, International, 2016.12, 日韓3女子大学交流合同シンポジウム, 梨花女子大学, 梨花女子大学, Not Invited, Coauthor

  • Functional characterization of variants detected in FABP genes in psychiatric illnesses

    Chie Shimamoto, Tetso Ohnishi, Motoko Maekawa, Akiko Watanabe, Tomoko Tomita, Manabu Toyoshima, Tetsuyuki Kobayashi, and Takeo Yoshikawa, Domestic, 2015.02, 6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015), Plaza Hotel, Shinjuku, Tokyo, International Conference on Phospholipase A2 and Lipid Mediators, Not Invited, Coauthor

  • Skin abnormalities in group III sPLA2-deficient mice

    Yuki Endo, Yoshitaka Taketomi, Kei Yamamoto, Tetsuyuki Kobayashi, and Makoto Murakami, Domestic, 2015.02, 6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015), Plaza Hotel, Shinjuku, Tokyo, International Conference on Phospholipase A2 and Lipid Mediators, Not Invited, Coauthor

  • Functional analyses of polymorphisms in brain-expressed fatty acid binding protein genes, FABP7, 5 and 3 in autism and schizophrenia.

    Chie Shimamoto, Tetsuo Ohnishi, Motoko Maekawa, Tomoko Toyota, Yoshimi Iwayama, Akiko Watanabe, Hisako Ohba, Yasuko Hisano, Yuina Wada, Chinatsu Tabata, Tamotsu Zako, Yuji Owada, Tetsuyuki Kobayashi, Takeo Yoshikawa., Domestic, 2013.12, Invited, Coauthor

  • Loss of white adipose tissue in mice deficient in PNPLA7, a lysophospholipase

    Misa Mouri, Tetsuya Hirabayashi, Tohru Shimamura, Tatsuki Anjo, Tetsuyuki Kobayashi, Makoto Murakami, Domestic, 2013.09, Not Invited, Coauthor

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Prize for Research Activities 【 display / non-display

  • Lands Award/Incentive Award

    日本脂質栄養学会, 小林哲幸, 食餌必須脂肪酸バランスと慢性疾患との連関における生化学的解析, 1995.09, Domestic

  • 三島海雲記念財団第40回学術奨励賞

    三島海雲記念財団, 小林哲幸, ステリルグルコシドによる抗潰瘍作用の解析, 2002.06, Domestic

Industrial Property 【 display / non-display

  • ヒアルロン酸産生能増強剤およびその用途

    山田信治ほか2名, 日本油脂株式会社

  • 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び/又は生存の促進のための薬剤

    室伏きみ子ほか2名, 株式会社ジェンコム