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Aya Tanatani
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Research Keywords 【 display / non-display 】
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functional molecule, Supramolecule, Aromatic amide, Drug Discovery, Nuclear Receptor
Research Pursuits 【 display / non-display 】
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Novel unique molecules in the field of materials sciences and medicinal chemistry are developed. Based on our finding about the conformational properties of aromatic amides and related functional groups, we develop aromatic molecules with unique three-dimensional structure and dynamic behaviors, such as aromatic multi-layered and helical molecules. Further, the molecules whose conformation is changed by the environmental stimuli are designed, and synthesized. In the field of medicinal chemistry, we develop the novel specific ligands for nuclear receptors, such as androgen, progesterone, and vitamin D receptors, and elucidate their biological functions.
Academic 【 display / non-display 】
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東京大学大学院, 薬学系研究科, 分子薬学専攻, 大学院（博士課程）, 1998.03, 修了, Japan
Campus Career 【 display / non-display 】
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Graduate School of Humanities and Sciences, Research Organization, the Core Section The Natural/Applied Sciences Division, Associate Professor, 2012.04 - 2015.03
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Faculty of Core Research Natural Sciences Division, Associate Professor, 2015.04 - 2020.03
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Faculty of Core Research Natural Sciences Division, Professor, 2020.04 -
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Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences, 2012.04 - 2015.03
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Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences, 2015.04 -
External Career 【 display / non-display 】
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University of Illinois at Urbana-Champaign Department of Chemistry and Materials & Engineering, Postdoctoral Fellow, 2000.01 - 2001.07
Research Field 【 display / non-display 】
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Life Science / Life Science / Pharmaceutical chemistry and drug development sciences
Class management data 【 display / non-display 】
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2024
Books 【 display / non-display 】
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Gene Family Based Molecular Design
Nuclear Receptor Drug Discovery, Wiley-Interscience, 2008.03, Hiroyuki Kagechika, and Aya Tanatani, Karen Lackey, Report, 275-316
Papers 【 display / non-display 】
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Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists.
Biomolecules, MDPI, , vol.12(p.130), 2022, Yoshihara, A.; Kawasaki, H.; Masuno, H.; Takada, K.; Numoto, N.; Ito, N.; Hirata, N.; Kanda, Y.; Ishizawa, M.; Makishima, M.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author
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A Potent and Selective cis-Amide Inhibitor of Ryanodine Receptor 2 as a Candidate for Cardiac Arrhythmia Treatment.
Eur. J. Med. Chem., Elsevier, (p.115910), 2023, Ishida, R.; Kurebayashi, N.; Iinuma, H.; Zeng, X.; Mori, S.; Kodama, M.; Murayama, T.; Masuno. H.; Takeda, H.; Kawahata, M.; Tanatani, A.; Kagechika, H., Original, Research paper (scientific journal), Coauthor
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Solvent-Dependent Conformational Switching of N-Methyl-N,N'-Diarylsquaramide.
J. Org. Chem., ACS, , vol.88(p.12289 - 12293), 2023, Tanaka, K.; Takeda, F.; Kanda, M.; Kawahata, M.; Fujii, S.; Katagiri, K.; Masu, H.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author
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An N-Cyanoamide Derivative of Lithocholic Acid Co-Operates with Lysophosphatidic Acid to Promote Human Osteoblast (MG63) Differentiation.
Biomolecules, MDPI, (13)(p.1113), 2023, Mansell, J. P.; Tanatani, A.; Kagechika, H., Original, Research paper (scientific journal), Capital Author
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Conformational Properties of Aromatic Amides Bearing Imidazole Ring and Acid-Induced Trans-Cis Amide Switching.
J. Org. Chem., ACS, (p.16707 - 16718), 2023, 4 Takubo, C.; Kimura, S.; Ichinomiya, M.; Hayakawa, A.; Murata, M.; Urushibara, K.; Masu, H.; Katagiri, K.; Kawahata, M.; Kudo, M.; Azumaya, I.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author
Presentations 【 display / non-display 】
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アミド類の立体特性に着目した新規FXRアゴニストの創製研究
中道絢香、石澤通康、槇島誠、馬悦、影近弘之、棚谷綾, Domestic, Poster presentation, 2024.03, 2024/03/292024/03/29, 日本薬学会第144年会, 横浜（日本）, 日本薬学会, Not Invited, Main Speaker
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Cis型アミド構造を有する新規ARアンタゴニストの創製
池田彩乃、石田良典、川幡正俊、片桐幸輔、影近弘之、棚谷綾, Domestic, Poster presentation, 2024.03, 2024/03/292024/03/29, 日本薬学会第144年会, 横浜（日本）, 日本薬学会, Not Invited, Main Speaker
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含窒素複素環を骨格とした新規ARアンタゴニストの創製
泉さらら、石田良典、影近弘之、棚谷綾, Domestic, Poster presentation, 2024.03, 2024/03/292024/03/29, 日本薬学会第144年会, 横浜（日本）, 日本薬学会, Not Invited, Main Speaker
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側鎖にカルバメート構造を有する新規リトコール酸誘導体のビタミンD活性
岡村佳奈、南真梨香、平田尚也、諫田泰成、石澤通康、槙島誠、増野弘幸、影近弘之、棚谷綾, Domestic, Poster presentation, 2024.03, 2024/03/292024/03/29, 日本薬学会第144年会, 横浜（日本）, 日本薬学会, Not Invited, Main Speaker
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cis型芳香族ウレアを骨格としたらせん分子触媒の開発
武田史、工藤まゆみ、小倉麻珠華、折原弥生、小田木陽、長澤和夫、棚谷綾, Domestic, Poster presentation, 2024.03, 2024/03/242024/03/24, 日本化学会第104春季年会, 東京（日本）, 日本化学会, Not Invited, Main Speaker
Prize for Research Activities 【 display / non-display 】
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平成２２年度文部科学大臣表彰若手科学者賞
文部科学省, Aya Tanatani, 機能性芳香族アミドフォルダマーの構築と動的立体制御の研究, 2010.04, Domestic
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日本薬学会奨励賞
日本薬学会, 棚谷 綾, 核内受容体活性制御仮説に基づく特異的リガンドの創製研究, 2006.03, Domestic
Industrial Property 【 display / non-display 】
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新規殺鼠剤
棚谷綾、影近弘之、長岡慧, 棚谷綾、影近弘之、長岡慧お茶の水女子大学、東京医科歯科大学、大丸合成薬品株式会社（年月日）
Application number (特願2024-11448, 2024.01.31) Publication number (特願2024-11448) Registration number (特願2024-11448, 2024.01.31)
Announcement Date (2024/01/31)Publication Date (2024/01/31)
Receipt of outside funds (Education, Research, Contribution to Society and industry-academia[government] collaboration) 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)2022, 1,200Thousand yen
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Grant-in-Aid for Scientific Research(C)2021, 1,100Thousand yen
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Grant-in-Aid for Scientific Research(C)2020, 1,000Thousand yen
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助成金2014, 2,000Thousand yen
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Grant-in-Aid for Scientific Research(C)2012, 1,400Thousand yen
Contributions as an officer, member, etc., of an academic society 【 display / non-display 】
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2018.04 - 2020.03，Committee Member, Domestic
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2012.05 - now，Committee Member, Domestic
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2010.07 - now，External Adviser, Domestic
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2010.06 - 2012.03，Committee Member, Domestic
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2009.04 - now，Committee Member, Domestic
Media coverage, appearances, commentary, etc. 【 display / non-display 】
- 日刊工業新聞
2013.07.31