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Aya Tanatani
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Research Keywords 【 display / non-display 】
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functional molecule, Supramolecule, Aromatic amide, Drug Discovery, Nuclear Receptor
Research Pursuits 【 display / non-display 】
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Novel unique molecules in the field of materials sciences and medicinal chemistry are developed. Based on our finding about the conformational properties of aromatic amides and related functional groups, we develop aromatic molecules with unique three-dimensional structure and dynamic behaviors, such as aromatic multi-layered and helical molecules. Further, the molecules whose conformation is changed by the environmental stimuli are designed, and synthesized. In the field of medicinal chemistry, we develop the novel specific ligands for nuclear receptors, such as androgen, progesterone, and vitamin D receptors, and elucidate their biological functions.
Academic 【 display / non-display 】
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東京大学大学院, 薬学系研究科, 分子薬学専攻, 大学院（博士課程）, 1998.03, 修了, Japan
Campus Career 【 display / non-display 】
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Graduate School of Humanities and Sciences, Research Organization, the Core Section The Natural/Applied Sciences Division, Associate Professor, 2012.04 - 2015.03
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Faculty of Core Research Natural Sciences Division, Associate Professor, 2015.04 - 2020.03
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Faculty of Core Research Natural Sciences Division, Professor, 2020.04 -
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Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences, 2012.04 - 2015.03
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Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences, 2015.04 -
External Career 【 display / non-display 】
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University of Illinois at Urbana-Champaign Department of Chemistry and Materials & Engineering, Postdoctoral Fellow, 2000.01 - 2001.07
Research Field 【 display / non-display 】
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Life Science / Life Science / Pharmaceutical chemistry and drug development sciences
Books 【 display / non-display 】
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Gene Family Based Molecular Design
Nuclear Receptor Drug Discovery, Wiley-Interscience, 2008.03, Hiroyuki Kagechika, and Aya Tanatani, Karen Lackey, Report, 275-316
Papers 【 display / non-display 】
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Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists.
Biomolecules, MDPI, , vol.12(p.130), 2022, Yoshihara, A.; Kawasaki, H.; Masuno, H.; Takada, K.; Numoto, N.; Ito, N.; Hirata, N.; Kanda, Y.; Ishizawa, M.; Makishima, M.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author
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A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-derived Iintestinal Organoids.
Bio. Pharma. Bull., , vol.45(p.1720 - 1724), 2022, Yamada, S.; Masuno, H.; Kagechika, H. Tanatani, A.; Kanda, Y., Original, Research paper (scientific journal), Coauthor
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Development of Retinoic Acid Receptor Antagonists Bearing trans-SF4- Alkynyl Structure as a Linear Linker.
Tetrahedron, Elsevier, , vol.123(p.132967 - ), 2022, 3 Mori, S.; Tsuemoto, N.; Kawachi, E.; Takubo, C.; Tanatani, A.; Kagechika, H., Original, Research paper (scientific journal), Coauthor
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Accessing improbable foldamer shapes with strained macrocycles
Chem.-A. Eur. J., , vol.27(p.11205 - 11215), 2021, Urushibara, K.; Ferrand, Y.; Liu, Z.; Katagiri, K.; Kawahata, M.; Morvan, E.; D'Elia, R.; Pophristic, V.; Tanatani, A.; Huc, I., Original, Research paper (scientific journal), Capital Author
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Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists.
J. Med. Chem., , vol.64(p.516 - 526), 2021, Sasaki, H.; Masuno, H.; Kawasaki, H.; Yoshihara, A.; Numoto, N.; Ito, N.; Ishida, H.; Yamamoto, K.; Hirata, N.; Kanda, Y.; Kawachi, E.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author
Presentations 【 display / non-display 】
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ビタミンD活性を有する新規リトコール酸誘導体の創製
南真梨果、 吉原綾菜、増野弘幸、平田尚也、諫田泰成、影近弘之、棚谷綾, Domestic, 2022.03, , 生体医歯工学共同研究拠点令和３年度成果報告会, オンライン, 東京医科歯科大学, Not Invited, Main Speaker
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COVID-19治療薬開発を目的とした ERリガンドの構造展開
岡村佳奈、棚谷綾、辻一徳、前田裕輔、影近弘之, Domestic, 2022.03, , 生体医歯工学共同研究拠点令和３年度成果報告会, オンライン, 東京医科歯科大学, Not Invited, Main Speaker
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ファルネソイドX受容体 (FXR) 機能制御を併せ持つビタミンD誘導体の創製
棚谷綾、藤原葉子, Domestic, 2022.03, , 第 371 回脂溶性ビタミン総合研究委員会, お茶の水女子大学ハイブリッド, 脂溶性ビタミン委員会, Invited, Main Speaker
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N-メチル-N,N'-ジフェニルスクアルアミドの溶媒依存的立体転換
田中希実子、神田翠、藤井晋也、片桐幸輔、川幡正俊、影近弘之、棚谷 綾, Domestic, 2022.03, , 日本化学会第102春季年会, オンライン, 日本化学会, Not Invited, Main Speaker
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イミダゾールアミドの立体特性を利用した動的フォルダマーの創製
木村彩紀子、田久保千晴、一宮麻未、片桐幸輔、川幡正俊、影近弘之、棚谷 綾, Domestic, 2022.03, , 日本化学会第102春季年会, オンライン, 日本化学会, Not Invited, Main Speaker
Prize for Research Activities 【 display / non-display 】
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平成２２年度文部科学大臣表彰若手科学者賞
文部科学省, Aya Tanatani, 機能性芳香族アミドフォルダマーの構築と動的立体制御の研究, 2010.04, Domestic
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日本薬学会奨励賞
日本薬学会, 棚谷 綾, 核内受容体活性制御仮説に基づく特異的リガンドの創製研究, 2006.03, Domestic
Receipt of outside funds (Education, Research, Contribution to Society and industry-academia[government] collaboration) 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)2022, 1,200Thousand yen
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Grant-in-Aid for Scientific Research(C)2021, 1,100Thousand yen
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Grant-in-Aid for Scientific Research(C)2020, 1,000Thousand yen
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助成金2014, 2,000Thousand yen
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Grant-in-Aid for Scientific Research(C)2012, 1,400Thousand yen
Contributions as an officer, member, etc., of an academic society 【 display / non-display 】
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2018.04 - 2020.03，Committee Member, Domestic
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2012.05 - now，Committee Member, Domestic
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2010.07 - now，External Adviser, Domestic
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2010.06 - 2012.03，Committee Member, Domestic
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2009.04 - now，Committee Member, Domestic
Media coverage, appearances, commentary, etc. 【 display / non-display 】
- 日刊工業新聞
2013.07.31