Research Keywords 【 display / non-display

  • functional molecule, Supramolecule, Aromatic amide, Drug Discovery, Nuclear Receptor

Research Pursuits 【 display / non-display

  • Novel unique molecules in the field of materials sciences and medicinal chemistry are developed. Based on our finding about the conformational properties of aromatic amides and related functional groups, we develop aromatic molecules with unique three-dimensional structure and dynamic behaviors, such as aromatic multi-layered and helical molecules. Further, the molecules whose conformation is changed by the environmental stimuli are designed, and synthesized. In the field of medicinal chemistry, we develop the novel specific ligands for nuclear receptors, such as androgen, progesterone, and vitamin D receptors, and elucidate their biological functions.

Campus Career 【 display / non-display

  • Graduate School of Humanities and Sciences, Research Organization, the Core Section The Natural/Applied Sciences Division, Associate Professor

  • Faculty of Core Research Natural Science Division, Associate Professor

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences

  • Graduate School of Humanities and Sciences, Education Organization, Master's Program Advanced Sciences

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External Career 【 display / non-display

  • University of Illinois at Urbana-Champaign Department of Chemistry and Materials & Engineering, Postdoctoral Fellow, 2000.01 - 2001.07

Research Field 【 display / non-display

 

Books 【 display / non-display

  • Gene Family Based Molecular Design

    Nuclear Receptor Drug Discovery, Wiley-Interscience, 2008.03, Hiroyuki Kagechika, and Aya Tanatani, Karen Lackey, Book, 275-316

Papers 【 display / non-display

  • Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists.

    Bioorg. Med. Chem., vol.23(p.803 - 809), 2015, MORI Shuichi, TAKEUCHI Yuki, TANATANI Aya, KAGECHIKA Hiroyuki, FUJII Shinya, Original, Research paper (scientific journal), Capital Author

  • Synthesis and Structure-activity Relationship of p-Carborane-based non-Secosteroid Vitamin D Analogs.

    Bioorg. Med. Chem., vol.22(p.1227 - 1235), 2014, 1 Fujii, S.; Kano, A.; Songkram, C.; Masuno, H.; Taoda, Y.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H., Original, Research paper (scientific journal), Coauthor

  • Structural Characterization of Partly-Folded Foldamers with No Long Range Conformational Order.

    Chem. Comm., vol.50(70)(p.10090 - 10093), 2014, Original, Research paper (scientific journal), Capital Author

  • Lipase-catalysed asymmetric acylation of boron cluster-containing secondary alcohols.

    Tetrahedron Asymmetry, vol.25(p.1505 - 1512), 2014, Original, Research paper (scientific journal), Coauthor

  • Design and Synthesis of Tetraol Derivatives of 1, 12-Dicarba-closo-dodecaborane as non-Secosteroidal Vitamin D Analogs.

    Bioorg. Med. Chem. Lett., vol.24(p.4515 - 4519), 2014, Original, Research paper (scientific journal), Coauthor

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Presentations 【 display / non-display

  • ビタミンD活性を有するリトコール酸アミド誘導体の創製

    吉岡千咲、川崎波留、佐々木晴江、増野弘幸、河内恵美子、伊藤暢聡、影近弘之、棚谷綾, Domestic, 2019.03, 日本薬学会第139年会, Chiba(Japan), 日本薬学会, Not Invited, Coauthor

  • ミネラルコルチコイドアンタゴニスト活性を有する新規アミドおよびスルフォンアミドの創製

    小西史香、森修一、影近弘之、棚谷綾, Domestic, 2019.03, 日本薬学会第139年会, Chiba(Japan), 日本薬学会, Not Invited, Coauthor

  • ビタミンD活性を有するリトコール酸誘導体の構造展開

    棚谷綾、吉岡千咲、川崎波留、佐々木晴江、藤原葉子、増野弘幸、伊藤暢聡、影近弘之, Domestic, 2019.03, 第361回脂溶性ビタミン総合研究委員会, Tokyo(Japan), 脂溶性ビタミン総合研究委員会, Not Invited, Main Speaker

  • Development of Nonsteroidal Mineralocorticoid Receptor Antagonists

    Fumika Konishi, Shuichi Mori, Hiroyuki Kagechika, Aya Tanatani, International, 2018.11, 9th Ewha-JWU-Ochanomizu Joint Symposium, Seoul(Korea), Ewha Woman University, Not Invited, Coauthor

  • N-Aryl-N’-cyanoformamidineの立体構造解析

    Domestic, 2015.03, 第135回日本薬学会年会, Kobe, 日本薬学会, Not Invited, Coauthor

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Prize for Research Activities 【 display / non-display

  • 平成22年度文部科学大臣表彰若手科学者賞

    文部科学省, Aya Tanatani, 機能性芳香族アミドフォルダマーの構築と動的立体制御の研究, 2010.04, Domestic

  • 日本薬学会奨励賞

    日本薬学会, 棚谷 綾, 核内受容体活性制御仮説に基づく特異的リガンドの創製研究, 2006.03, Domestic