Research Keywords 【 display / non-display

  • functional molecule, Supramolecule, Aromatic amide, Drug Discovery, Nuclear Receptor

Research Pursuits 【 display / non-display

  • Novel unique molecules in the field of materials sciences and medicinal chemistry are developed. Based on our finding about the conformational properties of aromatic amides and related functional groups, we develop aromatic molecules with unique three-dimensional structure and dynamic behaviors, such as aromatic multi-layered and helical molecules. Further, the molecules whose conformation is changed by the environmental stimuli are designed, and synthesized. In the field of medicinal chemistry, we develop the novel specific ligands for nuclear receptors, such as androgen, progesterone, and vitamin D receptors, and elucidate their biological functions.

Campus Career 【 display / non-display

  • Graduate School of Humanities and Sciences, Research Organization, the Core Section The Natural/Applied Sciences Division, Associate Professor

  • Faculty of Core Research Natural Science Division, Associate Professor

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences

  • Graduate School of Humanities and Sciences, Education Organization, Master's Program Advanced Sciences

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External Career 【 display / non-display

  • University of Illinois at Urbana-Champaign Department of Chemistry and Materials & Engineering, Postdoctoral Fellow, 2000.01 - 2001.07

Research Field 【 display / non-display

 

Books 【 display / non-display

  • Gene Family Based Molecular Design

    Nuclear Receptor Drug Discovery, Wiley-Interscience, 2008.03, Hiroyuki Kagechika, and Aya Tanatani, Karen Lackey, Book, 275-316

Papers 【 display / non-display

  • Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists.

    Bioorg. Med. Chem., vol.23(p.803 - 809), 2015, MORI Shuichi, TAKEUCHI Yuki, TANATANI Aya, KAGECHIKA Hiroyuki, FUJII Shinya, Original, Research paper (scientific journal), Capital Author

  • Synthesis and Structure-activity Relationship of p-Carborane-based non-Secosteroid Vitamin D Analogs.

    Bioorg. Med. Chem., vol.22(p.1227 - 1235), 2014, 1 Fujii, S.; Kano, A.; Songkram, C.; Masuno, H.; Taoda, Y.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H., Original, Research paper (scientific journal), Coauthor

  • Lipase-catalysed asymmetric acylation of boron cluster-containing secondary alcohols.

    Tetrahedron Asymmetry, vol.25(p.1505 - 1512), 2014, Original, Research paper (scientific journal), Coauthor

  • Design and Synthesis of Tetraol Derivatives of 1, 12-Dicarba-closo-dodecaborane as non-Secosteroidal Vitamin D Analogs.

    Bioorg. Med. Chem. Lett., vol.24(p.4515 - 4519), 2014, Original, Research paper (scientific journal), Coauthor

  • Structural Development of p-Carborane-based Potent non-Secosteroid Vitamin D Analogs.

    Bioorg. Med. Chem., vol.22(p.5891 - 5901), 2014, Original, Research paper (scientific journal), Coauthor

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Presentations 【 display / non-display

  • カルボラン含有プロゲステロン受容体リガンドのリパーゼによる光学分割

    Domestic, 2015.03, 第135回日本薬学会年会, Kobe, 日本薬学会, Not Invited, Coauthor

  • N-Aryl-N’-cyanoformamidineの立体構造解析

    Domestic, 2015.03, 第135回日本薬学会年会, Kobe, 日本薬学会, Not Invited, Coauthor

  • Lipase-catalyzed asymmetric acylation of boron cluster-containing secondary alcohols

    MORI Shuichi, TAKAGAKI Ryohei, FUJII Shinya, MATSUMURA Mio, TANATANI Aya, KAGECHIKA Hiroyuki, Domestic, 2014.12, Active Enzyme Molecule 2014, Toyama, Active Enzyme Molecule, Not Invited, Coauthor

  • Lipase-catalyzed optical resolution and biological activity of boron-cluster-based progesterone receptor ligands

    International, 2014.11, 第3回国際ケミカルバイオロジー学会, サンフランシスコ, 国際ケミカルバイオロジー学会, Not Invited, Coauthor

  • クマリン骨格を基盤としたアンドロゲンアンタゴニストの創製研究

    Domestic, 2014.11, 第32回メディシナルケミストリーシンポジウム, Kobe, 日本薬学会, Not Invited, Coauthor

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Prize for Research Activities 【 display / non-display

  • 平成22年度文部科学大臣表彰若手科学者賞

    文部科学省, Aya Tanatani, 機能性芳香族アミドフォルダマーの構築と動的立体制御の研究, 2010.04, Domestic

  • 日本薬学会奨励賞

    日本薬学会, 棚谷 綾, 核内受容体活性制御仮説に基づく特異的リガンドの創製研究, 2006.03, Domestic