Aya Tanatani


Position

Associate Professor

Birth

1970/11

Affiliation

Faculty of Core Research Natural Science Division

Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences

Graduate School of Humanities and Sciences, Education Organization, Master's Program Advanced Sciences

Faculty of Science Chemistry

Faculty

Chemistry

Education Organization (Master's Program)

Chemistry and Biochemistry

Education Organization (Doctoral Program)

Chemistry and Biochemistry

URL

写真a

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Research Keywords 【 display / non-display 】

  • functional molecule, Supramolecule, Aromatic amide, Drug Discovery, Nuclear Receptor

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Research Pursuits 【 display / non-display 】

  • Novel unique molecules in the field of materials sciences and medicinal chemistry are developed. Based on our finding about the conformational properties of aromatic amides and related functional groups, we develop aromatic molecules with unique three-dimensional structure and dynamic behaviors, such as aromatic multi-layered and helical molecules. Further, the molecules whose conformation is changed by the environmental stimuli are designed, and synthesized. In the field of medicinal chemistry, we develop the novel specific ligands for nuclear receptors, such as androgen, progesterone, and vitamin D receptors, and elucidate their biological functions.

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Campus Career 【 display / non-display 】

  • Graduate School of Humanities and Sciences, Research Organization, the Core Section The Natural/Applied Sciences Division, Associate Professor

  • Faculty of Core Research Natural Science Division, Associate Professor

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences

  • Graduate School of Humanities and Sciences, Education Organization, Master's Program Advanced Sciences

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External Career 【 display / non-display 】

  • University of Illinois at Urbana-Champaign Department of Chemistry and Materials & Engineering, Postdoctoral Fellow, 2000.01 - 2001.07

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Research Field 【 display / non-display 】

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Books 【 display / non-display 】

  • Gene Family Based Molecular Design

    Nuclear Receptor Drug Discovery, Wiley-Interscience, 2008.03, Hiroyuki Kagechika, and Aya Tanatani, Karen Lackey, Book, 275-316

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Papers 【 display / non-display 】

  • Accessing improbable foldamer shapes with strained macrocycles

    Chem.-A. Eur. J., vol.27(p.11205 - 11215), 2021, Urushibara, K.; Ferrand, Y.; Liu, Z.; Katagiri, K.; Kawahata, M.; Morvan, E.; D'Elia, R.; Pophristic, V.; Tanatani, A.; Huc, I., Original, Research paper (scientific journal), Capital Author

  • Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists.

    J. Med. Chem., vol.64(p.516 - 526), 2021, Sasaki, H.; Masuno, H.; Kawasaki, H.; Yoshihara, A.; Numoto, N.; Ito, N.; Ishida, H.; Yamamoto, K.; Hirata, N.; Kanda, Y.; Kawachi, E.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author

  • Construction of Aromatic Multilayered Structures Based on the Conformational Properties of N,N'-Dimethylated Squaramide.

    ChemPlusChem, vol.86(p.198 - 205), 2021, Arimura, M.; Tanaka, K.; Kanda, M.; Urushibara, K.; Fujii, S.; Katagiri, K.; Azumaya, I.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author

  • Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore.

    Int. J. Mol. Sci.(21)(p.5584 - ), 2020, Koga, H.; Negishi, M.; Kinoshita, M.; Fujii, S.; Mori, S.; Ishigami-Yuasa, M.; Kawachi, E.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author

  • Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists.

    Bioorg. Med. Chem., vol.23(p.803 - 809), 2015, MORI Shuichi, TAKEUCHI Yuki, TANATANI Aya, KAGECHIKA Hiroyuki, FUJII Shinya, Original, Research paper (scientific journal), Capital Author

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Presentations 【 display / non-display 】

  • ビタミンD活性を有する新規リトコール酸誘導体の創製

    南真梨果、 吉原綾菜、増野弘幸、平田尚也、諫田泰成、影近弘之、棚谷綾, Domestic, 2022.03, 生体医歯工学共同研究拠点令和３年度成果報告会, オンライン, 東京医科歯科大学, Not Invited, Main Speaker

  • COVID-19治療薬開発を目的とした ERリガンドの構造展開

    岡村佳奈、棚谷綾、辻一徳、前田裕輔、影近弘之, Domestic, 2022.03, 生体医歯工学共同研究拠点令和３年度成果報告会, オンライン, 東京医科歯科大学, Not Invited, Main Speaker

  • ファルネソイドX受容体 (FXR) 機能制御を併せ持つビタミンD誘導体の創製

    棚谷綾、藤原葉子, Domestic, 2022.03, 第 371 回脂溶性ビタミン総合研究委員会, お茶の水女子大学ハイブリッド, 脂溶性ビタミン委員会, Invited, Main Speaker

  • N-メチル-N,N'-ジフェニルスクアルアミドの溶媒依存的立体転換

    田中希実子、神田翠、藤井晋也、片桐幸輔、川幡正俊、影近弘之、棚谷 綾, Domestic, 2022.03, 日本化学会第102春季年会, オンライン, 日本化学会, Not Invited, Main Speaker

  • イミダゾールアミドの立体特性を利用した動的フォルダマーの創製

    木村彩紀子、田久保千晴、一宮麻未、片桐幸輔、川幡正俊、影近弘之、棚谷 綾, Domestic, 2022.03, 日本化学会第102春季年会, オンライン, 日本化学会, Not Invited, Main Speaker

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Prize for Research Activities 【 display / non-display 】

  • 平成２２年度文部科学大臣表彰若手科学者賞

    文部科学省, Aya Tanatani, 機能性芳香族アミドフォルダマーの構築と動的立体制御の研究, 2010.04, Domestic

  • 日本薬学会奨励賞

    日本薬学会, 棚谷　綾, 核内受容体活性制御仮説に基づく特異的リガンドの創製研究, 2006.03, Domestic

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