Aya Tanatani


Position

Professor

Birth

1970/11

Affiliation

Faculty of Core Research Natural Sciences Division

Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences

Graduate School of Humanities and Sciences, Education Organization, Master's Program Advanced Sciences

Faculty of Science Chemistry

Faculty

Chemistry

Education Organization (Master's Program)

Chemistry and Biochemistry

Education Organization (Doctoral Program)

Chemistry and Biochemistry

URL

写真a

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Research Keywords 【 display / non-display 】

  • functional molecule, Supramolecule, Aromatic amide, Drug Discovery, Nuclear Receptor

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Research Pursuits 【 display / non-display 】

  • Novel unique molecules in the field of materials sciences and medicinal chemistry are developed. Based on our finding about the conformational properties of aromatic amides and related functional groups, we develop aromatic molecules with unique three-dimensional structure and dynamic behaviors, such as aromatic multi-layered and helical molecules. Further, the molecules whose conformation is changed by the environmental stimuli are designed, and synthesized. In the field of medicinal chemistry, we develop the novel specific ligands for nuclear receptors, such as androgen, progesterone, and vitamin D receptors, and elucidate their biological functions.

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Academic 【 display / non-display 】

  • 東京大学大学院, 薬学系研究科, 分子薬学専攻, 大学院（博士課程）, 1998.03, 修了, Japan

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Degree 【 display / non-display 】

  • 博士（薬学）, 東京大学大学院, 1998.03

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Campus Career 【 display / non-display 】

  • Graduate School of Humanities and Sciences, Research Organization, the Core Section The Natural/Applied Sciences Division, Associate Professor, 2012.04 - 2015.03

  • Faculty of Core Research Natural Sciences Division, Associate Professor, 2015.04 - 2020.03

  • Faculty of Core Research Natural Sciences Division, Professor, 2020.04 -

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences, 2012.04 - 2015.03

  • Graduate School of Humanities and Sciences, Education Organization, Doctral Program Advanced Sciences, 2015.04 -

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External Career 【 display / non-display 】

  • University of Illinois at Urbana-Champaign Department of Chemistry and Materials & Engineering, Postdoctoral Fellow, 2000.01 - 2001.07

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Research Field 【 display / non-display 】

  • Life Science / Life Science / Pharmaceutical chemistry and drug development sciences

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Books 【 display / non-display 】

  • 医療工学研究の最前線～近未来のバイオ医用機器, 生体材料, 創薬科学～

    核内受容体の医薬化学, シーエムシー出版, 2024, 影近弘之、棚谷綾, 三林浩二、影近弘之、岸田晶夫, Scholarly book, 211-220

  • 超分子サイエンス＆テクノロジー−基礎からイノベーションまで

    フォルダマー, NTS, 2009, 影近弘之、棚谷綾, 国武豊喜監修, Scholarly book, 467-476

  • Gene Family Based Molecular Design

    Nuclear Receptor Drug Discovery, Wiley-Interscience, 2008.03, Hiroyuki Kagechika, and Aya Tanatani, Karen Lackey, Report, 275-316

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Papers 【 display / non-display 】

  • Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists.

    J. Med. Chem., , vol.64(p.516 - 526), 2021, Sasaki, H.; Masuno, H.; Kawasaki, H.; Yoshihara, A.; Numoto, N.; Ito, N.; Ishida, H.; Yamamoto, K.; Hirata, N.; Kanda, Y.; Kawachi, E.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author

  • Frustrated Helicity: Joining the Diverging Ends of a Stable Aromatic Amide Helix to Form a Fluxional Macrocycle.

    Angew. Chem. Int. Ed., , vol.57(p.7888 - 7892), 2018, Urushibara, K.; Ferrand, Y.; Liu, Z.; Masu, H.; Pophristic, V.; Tanatani, A.; Huc, I., Original, Research paper (scientific journal), Capital Author

  • Aromatic layered foldamer based on (cis, cis)-squaramide: Chiral induction and absolute structure

    Org. Biomol. Chem., RSC, , vol.23(p.4927 - 4933), 2025.04, Kuyama, K.; Takeda, F.; Ikeda, A,; Tanaka, K.; Katagiri, K.; Kawahata, M.; Okada, Y.; Kobayashi, N.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author

  • Acid-induced conformational switching of helical foldamers containing imidazole amide

    Bull. Chem. Soc. Jpn, The Chemical Society of Japan, , vol.97(9)(p.uoae094 - ), 2024.09, Kimura, S.; Takeda, F.; Ikeda, A,; Tanimoto, A.; Katagiri, K.; Kawahata, M.; Okada, Y.; Kobayashi, N.; Kagechika, H.; Tanatani, A., Original, Research paper (scientific journal), Capital Author

  • A Potent and Selective cis-Amide Inhibitor of Ryanodine Receptor 2 as a Candidate for Cardiac Arrhythmia Treatment.

    Eur. J. Med. Chem., Elsevier, (p.115910), 2023, Ishida, R.; Kurebayashi, N.; Iinuma, H.; Zeng, X.; Mori, S.; Kodama, M.; Murayama, T.; Masuno. H.; Takeda, H.; Kawahata, M.; Tanatani, A.; Kagechika, H., Original, Research paper (scientific journal), Coauthor

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Presentations 【 display / non-display 】

  • 高殺鼠活性ビタミンD誘導体 Dcha-20 のプロドラッグ化の検討

    小倉千春、吉原実唯菜、深松美咲、鎌田亮、武田一貴、長岡慧、影近弘之、棚谷綾, Domestic, Oral presentation (general), 2026.03, 2026/03/262026/03/29, 日本薬学会第146年会, 大阪, 日本薬学会, Not Invited, Main Speaker

  • ビタミンD誘導体Dcha-20誘導体の殺鼠活性機序の検討

    吉原実唯菜、小倉千春、岡村佳奈、深松美咲、鎌田亮、武田一貴、長岡慧、影近弘之、棚谷綾, Domestic, Poster presentation, 2026.03, 2026/03/262026/03/29, 日本薬学会第146年会, 大阪, 日本薬学会, Not Invited, Main Speaker

  • 動的な軸不斉を有する芳香族ウレア誘導体の立体特性と不斉有機触媒能

    武田史、工藤まゆみ、小林長夫、山中正弘、長澤和夫、棚谷綾, Domestic, Poster presentation, 2026.03, 2026/03/172026/03/20, 日本化学会第106春季年会, 東京, 日本化学会, Not Invited, Main Speaker

  • ピリジルスクアルアミドの光照射による構造変化

    中川さくら、永井暁、影近弘之、棚谷綾, Domestic, Poster presentation, 2026.03, 2026/03/172026/03/20, 日本化学会第106春季年会, 東京, 日本化学会, Not Invited, Main Speaker

  • 芳香族アミドの立体依存的な電子輸送特性

    城所裕衣、久山和紗、Rajarshi Samajdar、Xiaolin Liu、武田史、岡本巌、川幡正俊、片桐幸輔、Jeffrey S. Moore、Charles M. Schroeder、棚谷綾, Domestic, Poster presentation, 2026.03, 2026/03/172026/03/20, 日本化学会第106春季年会, 東京, 日本化学会, Not Invited, Main Speaker

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Prize for Research Activities 【 display / non-display 】

  • 平成２２年度文部科学大臣表彰若手科学者賞

    文部科学省, Aya Tanatani, 機能性芳香族アミドフォルダマーの構築と動的立体制御の研究, 2010.04, Domestic

  • 日本薬学会奨励賞

    日本薬学会, 棚谷　綾, 核内受容体活性制御仮説に基づく特異的リガンドの創製研究, 2006.03, Domestic

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Industrial Property 【 display / non-display 】

  • 新規殺鼠剤

    棚谷綾、影近弘之、長岡慧, 棚谷綾、影近弘之、長岡慧お茶の水女子大学、東京医科歯科大学、大丸合成薬品株式会社（年月日）

    Application number (特願2024-11448, 2024.01.31)  Publication number (特願2024-11448) Registration number (特願2024-11448, 2024.01.31)

    Announcement Date (2024/01/31)Publication Date (2024/01/31)

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Receipt of outside funds (Education, Research, Contribution to Society and industry-academia[government] collaboration) 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)2022, 1,200,000yen

  • Grant-in-Aid for Scientific Research(C)2021, 1,100,000yen

  • Grant-in-Aid for Scientific Research(C)2020, 1,000,000yen

  • 助成金2014, 2,000,000yen

  • Grant-in-Aid for Scientific Research(C)2012, 1,400,000yen

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Contributions as an officer, member, etc., of an academic society 【 display / non-display 】

  • 2025.04 - 2027.03，Committee Member, Academic society, research group, etc., Domestic

  • 2025.04 - 2026.03，Committee Member, Scientific advice/Review, Domestic

  • 2021.04 - 2023.03，Committee Member, Scientific advice/Review, Domestic

  • 2012.05 - now，Committee Member, Domestic

  • 2010.07 - now，External Adviser, Domestic

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Media coverage, appearances, commentary, etc. 【 display / non-display 】

  • 日刊工業新聞

    2013.07.31

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