論文 - 大金　賢司

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  1. In-gel refolding allows fluorescence detection of fully denatured GFPs after SDS-PAGE

    Analytical Biochemistry, Elsevier, 702巻(頁115861), 2025年04月, Misa Shiratori, Rio Tsuyuki, Miwako Asanuma, Saki Kawabata, Hiromasa Yoshioka, Kenji Ohgane, 原著, 研究論文（学術雑誌）, 第一著者相当

  2. Synthesis and Biological Assessment of Eucalyptin: Magic Methyl Effects

    International Journal of Molecular Sciences, MDPI, 26巻7号(頁3391 - ), 2025年04月, Kanta Fuchiyama, Yuka Yabuki, Yuzu Yamamoto, Ryuki Asakawa, Saki Matsumoto, Yuuka Ibayashi, yuuki furuyama, Kenji Ohgane, Shinji Kamisuki, Koichi Watashi, Makoto Matsubayashi, Kouji Kuramochi, 原著, 研究論文（学術雑誌）, 共著者

  3. Clozapine as an E3 Ligand for PROTAC Technology

    ACS Medicinal Chemistry Letters, , 16巻2号(頁258 - 262), 2025年02月, Reina Takano, Nobumichi Ohoka, Takashi Kurohara, Noriaki Arakawa, Kenji Ohgane, Takao Inoue, Hidetomo Yokoo, Yosuke Demizu, 原著, 研究論文（学術雑誌）, 共著者

  4. Phenylboronic acids as pH-selective ligands for arylsulfatase B: a lead for pharmacological chaperones against Maroteaux–Lamy syndrome

    chemRxiv, American Chemical Society (ACS), 2025年01月, Fumika Karaki, Kyoko Hidaka, Yuko Nishiyama, Ami Taniguchi, Yuichi Hashimoto, Kenji Ohgane, Hideaki Fujii, 原著, 研究論文（学術雑誌）, 第一著者相当

  5. In-gel refolding allows fluorescence detection of fully denatured GFPs after SDS-PAGE

    bioRxiv, , 2024年10月, Misa Shiratori, Rio Tsuyuki, Miwako Asanuma, Saki Kawabata, Hiromasa Yoshioka, Kenji Ohgane, 原著, 研究論文（学術雑誌）, 第一著者相当

  6. Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells.

    Bioorganic & medicinal chemistry letters, , 110巻(頁129886 - ), 2024年09月, Misaki Kabasawa, Masateru Furuta, Yuuka Ibayashi, Kaori Kanemaru, Haruki Kohatsu, Fumiyo Kuramochi, Kenji Yamatoya, Kazuya Nakata, Yoshikazu Nakamura, Shusuke Tomoshige, Kenji Ohgane, Yuuki Furuyama, Ryoko Takasawa, Susumu Kobayashi, Fumio Sugawara, Masahiko Ikekita, Kouji Kuramochi, 原著, 研究論文（学術雑誌）, 共著者

  7. Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies

    JCI Insight, , 9巻20号(頁e179525 - ), 2024年08月, Ruth D. Azaria, Adele B. Correia, Kylie J. Schache, Manuela Zapata, Koralege C. Pathmasiri, Varshasnata Mohanty, Dharma T. Nannapaneni, Brandon L. Ashfeld, Paul Helquist, Olaf Wiest, Kenji Ohgane, Qingqing Li, Ross A. Fredenburg, Brian S.J. Blagg, Stephanie M. Cologna, Mark L. Schultz, Andrew P. Lieberman, 原著, 研究論文（学術雑誌）, 共著者

  8. A small-molecule degron with a phenylpropionic acid scaffold

    Bioorganic & Medicinal Chemistry, Elsevier, 109巻(頁117789 - ), 2024年07月, Shusuke Tomoshige, Fumiko Komatsu, Tomoko Kikuchi, Miku Sugiyama, Yushi Kawasaki, Kenji Ohgane, Yuuki Furuyama, Shinichi Sato, Minoru Ishikawa, Kouji Kuramochi, 原著, 研究論文（学術雑誌）, 共著者

  9. Anti-hepatitis C Virus Activity of Juglorubin Derivatives

    Chem Pharm Bull, , 71巻11号(頁843 - 845), 2023年11月, OHASHI Hirofumi, NISHIOKA Kazane, KURIHARA Tomoki, NAKAMURA Kou, YAMASAKI Masako, IBAYASHI Yuuka, FUCHIYAMA Kanta, KAMO Shogo, FURUYAMA Yuuki, OHGANE Kenji, OKADA Maiko, KAMISUKI Shinji, WATASHI Koichi, KURAMOCHI Kouji, 原著, 研究論文（学術雑誌）, 共著者

  10. Lysine long-chain fatty acylation regulates the TEAD transcription factor.

    Cell reports, Cell Press, 42巻4号(頁112388 - ), 2023年04月, Kota Noritsugu, Takehiro Suzuki, Kosuke Dodo, Kenji Ohgane, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, Naoshi Dohmae, Minoru Yoshida, Akihiro Ito, 原著, 研究論文（学術雑誌）, 共著者

  11. Fine-tuning of nitrogen-containing bisphosphonate esters that potently induce degradation of HMG-CoA reductase

    Bioorganic & Medicinal Chemistry, Elsevier, 78巻(頁117145 - ), 2022年12月, Kota Kawamura, Hiromasa Yoshioka, Chikako Sato, Tomoko Yajima, Yuuki Furuyama, Kouji Kuramochi, Kenji Ohgane, 原著, 研究論文（学術雑誌）, 第一著者相当

  12. Synthesis and cytotoxic activities of 8- and 6-demethyleucalyptins

    Bioscience, Biotechnology, and Biochemistry, , 86巻9号(頁1200 - 1206), 2022年08月, ASAKAWA Ryuki, FUCHIYAMA Kanta, ISHII Yunosuke, HOSAKA Keisuke, KOBAYASHI Atsushi, SHIMAZAKI Kei, NAGASAWA Junki, TSUCHIDA Sayaka, USHIDA Kazunari, MATSUBAYASHI Makoto, FURUYAMA Yuuki, OHGANE Kenji, KURAMOCHI Kouji, 原著, 研究論文（学術雑誌）, 共著者

  13. Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties

    ACS Medicinal Chemistry Letters, , 2022年02月, HIRAI Keigo, YAMASHITA Hiroko, TOMOSHIGE Shusuke, MISHIMA Yugo, NIWA Tatsuya, OHGANE Kenji, ISHII Mayumi, KANAMITSU Kayoko, IKEMI Yui, NAKAGAWA Shinsaku, TAGUCHI Hideki, SATO Shinichi, HASHIMOTO Yuichi, ISHIKAWA Minoru, 原著, 研究論文（学術雑誌）, 共著者

  14. Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives

    Journal of Natural Products, , 85巻1号(頁284 - 291), 2022年01月, NISHIUCHI Kota, OHASHI Hirofumi, NISHIOKA Kazane, YAMASAKI Masako, FURUTA Masateru, MASHIKOTakumi, TOMOSHIGE Shusuke, OHGANE Kenji, KAMISUKI Shinji, WATASHI Koichi, KURAMOCHI Kouji, 原著, 研究論文（学術雑誌）, 共著者

  15. Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile

    Tetrahedron Letters, , 86巻(頁153519), 2021年12月, KATO Yuichi, INOUE Tomoka, FURUYAMA Yuuki, OHGANE Kenji, SADAIE Mahito, KURAMOCHI Kouji, 原著, 研究論文（学術雑誌）, 共著者

  16. Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules

    Organic & Biomolecular Chemistry, , 2021年09月, Syusuke Egoshi, Kosuke Dodo, Kenji Ohgane, Mikiko Sodeoka, 原著, 研究論文（学術雑誌）, 共著者

  17. Epo-C12 inhibits peroxiredoxin 1 peroxidase activity

    Bioorganic & Medicinal Chemistry, , 41巻(頁116203 - ), 2021年07月, Tomoka Yoda, Masateru Furuta, Tomohiko Tsutsumi, Seiki Ikeda, Shunsuke Yukizawa, Satoshi Arai, Akinori Morita, Kenji Yamatoya, Kazuya Nakata, Shusuke Tomoshige, Kenji Ohgane, Yuuki Furuyama, Kengo Sakaguchi, Fumio Sugawara, Susumu Kobayashi, Masahiko Ikekita, Kouji Kuramochi, 原著, 研究論文（学術雑誌）, 共著者

  18. SYNTHESIS, PHOTOCHEMICAL PROPERTIES, AND CYTOTOXICITY OF 10-ALKYLPHENAZIN-2(10H)-ONES

    Heterocycles, , 102巻5号(頁871 - 885), 2021年05月, KOHATSU Haruki, KAMO Shogo, HOSOKAI Takuya, KAMISUKI Shinji, MACHIDA Yutaro, KOBAYASHI Ryota, KAWASAKI Tsuneomi, OHGANE Kenji, KURAMOCHI Kouji, 原著, 研究論文（学術雑誌）, 共著者

  19. Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs

    PLOS ONE, , 15巻12号(頁e0243746 - ), 2020年12月, Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane, 原著, 研究論文（学術雑誌）, 第一著者相当

  20. Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation

    Bioorganic & Medicinal Chemistry, , 28巻14号(頁115576 - ), 2020年05月, Yosuke Toyota, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto, Kenji Ohgane, 原著, 研究論文（学術雑誌）, 第一著者相当

  21. A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

    Proceedings of the National Academy of Sciences, , 117巻13号(頁7150 - 7158), 2020年03月, Hiromasa Yoshioka, Hudson W. Coates, Ngee Kiat Chua, Yuichi Hashimoto, Andrew J. Brown, Kenji Ohgane, 原著, 研究論文（学術雑誌）, 第一著者相当

  22. Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols

    Bioorganic & Medicinal Chemistry, , 28巻3号(頁115298 - ), 2020年02月, Ikuya Sagimori, Hiromasa Yoshioka, Yuichi Hashimoto, Kenji Ohgane, 原著, 研究論文（学術雑誌）, 第一著者相当

  23. Application of Protein Knockdown Strategy Targeting β-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins

    Bioorganic & Medicinal Chemistry, , 28巻1号(頁115175 - ), 2019年10月, Hiroko Yamashita, Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa, 原著, 研究論文（学術雑誌）, 共著者

  24. Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton

    Bioorganic & Medicinal Chemistry, , 27巻10号(頁1952 - ), 2019年05月, Nanjyo S, Ohgane K, Yoshioka H, Makishima M, Hashimoto Y, Noguchi-Yachide T, 原著, 研究論文（学術雑誌）, 第一著者相当

  25. Multiplexing fluorogenic esterase-based viability assay with luciferase assays

    MethodsX, , 6巻(頁2013 - 2020), 2019年, Kenji Ohgane, Hiromasa Yoshioka, Yuichi Hashimoto, 原著, 研究論文（学術雑誌）, 第一著者相当

  26. Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative

    Bioorganic and Medicinal Chemistry Letters, , 28巻4号(頁707 - 710), 2018年02月, Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa, 原著, 研究論文（学術雑誌）, 共著者

  27. Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands

    Heterocycles, , 97巻2号(頁854 - 864), 2018年, SHIOI Ryuta, TOYOTA Yosuke, NOGUCHI-YACHIDE Tomomi, ISHIKAWA Minoru, YAMAGUCHI Takao, MAKISHIMA Makoto, HASHIMOTO Yuichi, OHGANE Kenji, 原著, 研究論文（学術雑誌）, 第一著者相当

  28. Discovery of Small Molecules that Induce the Degradation of Huntingtin

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, , 56巻38号(頁11530 - 11533), 2017年09月, TOMOSHIGE Shusuke, NOMURA Sayaka, OHGANE Kenji, HASHIMOTO Yuichi, ISHIKAWA Minoru, 原著, 研究論文（学術雑誌）, 共著者

  29. Reactivity of 7-Azanorbornenes in Bioorthogonal Inverse Electron-Demand Diels-Alder Reactions

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, , 2017巻26号(頁3815 - 3829), 2017年07月, KARAKI Fumika, OHGANE Kenji, IMAI Hirotaka, ITOH Kennosuke, FUJII Hideaki, 原著, 研究論文（学術雑誌）, 共著者

  30. Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, , 27巻12号(頁2781 - 2787), 2017年06月, FUKUDA Hiromitsu, KARAKI Fumika, DODO Kosuke, NOGUCHI-YACHIDE Tomomi, ISHIKAWA Minoru, HASHIMOTO Yuichi, OHGANE Kenji, 原著, 研究論文（学術雑誌）, 第一著者相当

  31. Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, , 24巻15号(頁3480 - 3485), 2014年08月, OHGANE Kenji, KARAKI Fumika, NOGUCHI-YACHIDE Tomomi, DODO Kosuke, HASHIMOTO Yuichi, 原著, 研究論文（学術雑誌）, 第一著者相当

  32. Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout

    BIOORGANIC & MEDICINAL CHEMISTRY, , 22巻14号(頁3587 - 3609), 2014年07月, KARAKI Fumika, OHGANE Kenji, FUKUDA Hiromitsu, NAKAMURA Masahiko, DODO Kosuke, HASHIMOTO Yuichi, 原著, 研究論文（学術雑誌）, 第一著者相当

  33. Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect

    BIOORGANIC & MEDICINAL CHEMISTRY, , 21巻17号(頁5297 - 5309), 2013年09月, KARAKI Fumika, OHGANE Kenji, DODO Kosuke, HASHIMOTO Yuichi, 原著, 研究論文（学術雑誌）, 第一著者相当

  34. Discovery of Oxysterol-Derived Pharmacological Chaperones for NPC1: Implication for the Existence of Second Sterol-Binding Site

    CHEMISTRY & BIOLOGY, , 20巻3号(頁391 - 402), 2013年03月, OHGANE Kenji, KARAKI Fumika, DODO Kosuke, HASHIMOTO Yuichi, 原著, 研究論文（学術雑誌）, 第一著者相当

  35. Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one Skeleton

    JOURNAL OF MEDICINAL CHEMISTRY, , 55巻17号(頁7360 - 7377), 2012年09月, AOYAMA Atsushi, ENDO-UMEDA Kaori, KISHIDA Kenji, OHGANE Kenji, NOGUCHI-YACHIDE Tomomi, AOYAMA Hiroshi, ISHIKAWA Minoru, MIYACHI Hiroyuki, MAKISHIMA Makoto, HASHIMOTO Yuichi, 原著, 研究論文（学術雑誌）, 共著者

  36. Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist.

    Bioorganic & medicinal chemistry, , 20巻11号(頁3460 - 3464), 2012年06月, BAN Shintaro, OYAMA Takuji, KASUGA Jun-ichi, OHGANE Kenji, NISHIO Yoshino, MORIKAWA Kosuke, HASHIMOTO Yuichi, MIYACHI Hiroyuki, 原著, 研究論文（学術雑誌）, 共著者

  37. フォールディング・トラフィッキング異常の修正作用を有するリガンドの創製 ～網膜色素変性症への応用を目指した変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究～

    薬学雑誌, , 131巻3号(頁325 - 334), 2011年03月, 大金　賢司・どど　孝介・橋本　祐一, 総説, 研究論文（学術雑誌）, 第一著者相当

  38. Retinobenzaldehydes as proper-trafficking inducers of folding-defective P23H rhodopsin mutant responsible for Retinitis Pigmentosa

    BIOORGANIC & MEDICINAL CHEMISTRY, , 18巻19号(頁7022 - 7028), 2010年10月, OHGANE Kenji, DODO Kosuke, HASHIMOTO Yuichi, 原著, 研究論文（学術雑誌）, 第一著者相当

  39. Peroxisome proliferator-activated receptor (PPAR) agonists with 3,4-dihydro-2H-benzo[e][1,3]oxazine and 2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine skeletons: Effects of cyclization of linker moiety on PPAR-agonistic activity

    HETEROCYCLES, , 75巻9号(頁2187 - 2192), 2008年09月, OHGANE Kenji, KASUGA Jun-ichi, OHYAMA Takuji, HIRAKAWA Yuko, Morikawa Kosuke, MAKISHIMA Makoto, HASHIMOTO Yuichi, MIYACHI Hiroyuki, 原著, 研究論文（学術雑誌）, 第一著者相当

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